Severe blistering skin rashes yellowing skin and eyes jaundice gastrointestinal bleeding weakness with shortness of breath severe headaches swelling severe flu-like symptoms. Grade 1-2 side effects less severe are much more common than grade 3-4 problems.

Pdf Imatinib Mesylate Gleevec Hepatotoxicity

The most common side effects of Gleevec are swelling around the eyes and legs as well as diarrhea nausea vomiting muscle cramps muscle or bone pain abdominal pain fatigue excessive gas and rash.

Side effects of gleevec for gist. Although not all of these side effects may occur if they do occur they may need medical attention. Gleevec is much more selective and as a result has fewer side effects. Talk to your care team about these recommendations.

I cant take nsaidsi am on a combination of duragesic and vicodanany. The lead author of the study stated that although one year of postoperative Gleevec is currently the standard of care for early GIST these results are very compelling. 22 years experience Hematology and Oncology.

Side effects of gleevec imatinib. More serious side effects can include high blood pressure increased risk of bleeding swelling heart problems and serious liver problems. Common Side Effects of GLEEVEC.

Gleevec was filed for registration based on the striking results of Phase II clinical trials and received approval from the European Union EU May 31 2002 the Food and Drug Administration FDA in the United States February 1 2002 and other countries for the. What Are Side Effects of Gleevec. Tell your doctor if you have serious side effects of Gleevec including.

By the end of therapy with Gleevec 14 of the group treated for 3 years and 8 of the group treated for one year had discontinued therapy due to side effects. Tell your doctor if you have serious side effects of. Your doctor should always be involved in the process of managing side effects because he or she can monitor conditions such as high blood pressure while perhaps prescribing other medications to deal with problems such as edema or nausea.

Regorafenib Stivarga Regorafenib can be used to treat advanced GISTs if imatinib and sunitinib stop working or if a person cant take these drugs for some reason. The severity of some side effects may be reduced with the help of other medicines and advice from your doctor while others may require stopping GLEEVEC therapy for a while or changing the dose. There are a number of things you can do to manage the side effects of imatinib.

They can help you decide what will work best for you. Common side effects of Gleevec include. Gleevec imatinib is a kinase inhibitor used to treat chronic myeloid leukemia CML and acute lymphoblastic leukemia ALL.

If you are experiencing any of the above-mentioned side effects please be sure to speak with your doctor immediately. Side effects of gleevec for gist. Sunitinib is used to treat a GIST that continues to grow even after treatment with imatinib.

Fluid retention such as extra water in tissue around eyes or in legs 71 - 76 Muscle or joint pain 37 Fatigue 30 - 39 Nausea 28 - 51. Fluid retention holding water Muscle cramps pain or bone pain. Almost all patients treated with GLEEVEC experience side effects at some time.

The most commonly occurring side effects reported in this study include anemia edema fatigue fever myalgia muscle achescramps anorexia diarrhea infection and skin rash. The side effects of sunitinib include fatigue diarrhea nausea and vomiting heartburn changes in taste high blood pressure low blood counts and changing skin color. Possible Side Effects of Imatinib.

The more common side effects of Gleevec can include. Common side effects of Gleevec include fluid retention headache diarrhea loss of appetite weakness nausea and vomiting abdominal distention swelling of arms and legs rash itching fever dizziness and muscle pain. Some common side effects that you may experience include.

Muscle or joint pain muscle cramps feeling tired dizziness blurred vision drowsiness skin rash flu-like symptoms stuffy nose or. Nausea stomach pain or upset vomiting diarrhea gas headache. A 28-year-old male asked.

GIST medications have many side effects some severe and some more manageable with the help of your doctor. Abdominal or stomach pain cramping burning or tenderness. Specifically it is used for chronic myelogenous leukemia CML and acute lymphocytic leukemia ALL that are Philadelphia chromosome-positive Ph certain types of gastrointestinal stromal tumors GIST hypereosinophilic syndrome HES chronic eosinophilic leukemia CEL.

However in some cases GLEEVEC therapy may need to be discontinued. What is the definition or description of. I had a 5 cm Gastrointestinal Stroma Tumor removed from my stomach about a year ago and have been on Gleevec 400 mg since Nov.

Bleeding from wound after surgery. One of the side effects of gleevec imatinib is bone pain. These are some of the most common or important side effects.

Sunitinib may also be used when the side effects of imatinib are too serious. Main side effects are occasional muscle cramping that can be intense mild periorbital edema mild-moderate nausea. Check with your doctor immediately if any of the following side effects occur while taking imatinib.

Side effects sometimes have percentage ranges because they differed between clinical studies. Fatigue lack of energy edema swelling typically in your legs ankles or feet and around your eyes muscle cramps or. In clinical studies the most commonly reported side effects with Imatinib are shown here.

Imatinib sold under the brand name Gleevec among others is an oral chemotherapy medication used to treat cancer.